KINSHIP OF CONDITIONALLY IMMORTALIZED CELLS DERIVED FROM FETAL BONE TO HUMAN BONE-DERIVED MESENCHYMAL STROMA CELLS

Kinship of conditionally immortalized cells derived from fetal bone to human bone-derived mesenchymal stroma cells

Abstract The human fetal osteoblast cell line (hFOB 1.19) has been proposed as an accessible experimental model for study of osteoblast biology relating to drug development and biomaterial engineering.For their multilineage differentiation potential, hFOB has been compared to human mesenchymal progenitor cells and used to investigate bone-metabolis

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Unleashing the Full Potential of Oncolytic Adenoviruses against Cancer by Applying RNA Interference: The Force Awakens

Oncolytic virus therapy of cancer is an actively pursued field of research.Viruses that were once considered as pathogens threatening the wellbeing of humans and animals alike are with every passing decade more Portable Sinks prominently regarded as vehicles for genetic and oncolytic therapies.Oncolytic viruses kill cancer cells, sparing healthy ti

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Ex Ante Allusions

We tend to think of allusions as indirect references to objects that already exist.Here I argue against this post facto orthodoxy and for the view that certain cases of allusion count as ex ante allusions (i.e.allusions before Hair Accessory the fact).I argue that the standard view conflates the epistemic dependence of allusion (knowledge of the ob

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Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.

We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control.R1c mAb also caused weight loss in leptin-deficient ob/ob mice, leptin receptor-mutant db/db

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